Dept. of Chemistry and Physics
- Ohio State University - Ph.D. - Physics, 2010
- Ohio State University - M.S. - Physics, 2007
- Yeshiva University (Honors) - B.A. - Physics (Math Minor), Valedictorian, 2005
- Ph.D. Dissertation: Oxidoreductase Immobilization in Reprecipitated Polyaniline Nanostructures for Optical Biosensing Applications (Adviser: Arthur J. Epstein)
- Undergraduate Thesis: Effect of Interface Disorder on Charge Transport through Quantum Wells
- Experimental Biophysics
- Antibiotic Resistance in Bacteria
- Organic Photovoltaics
- Shannon Information Entropy in DNA
Antibiotic Resistance in Bacteria: Over time, antibiotic drugs lose potency as bacteria evolve mechanisms to resist their effects. Excessive use of antibiotics has hastened this process, as susceptible bacteria are selectively killed, allowing the resistant bacteria to proliferate. Our ongoing research attempts to identify the conditions that are most likely to give rise to antibiotic resistance. We do so using a combination of theoretical models, computer simulations, and experiments with bacteria. The goal is to discover actionable information to guide clinical decisions regarding how antibiotics are prescribed and administered.
Biomolecule Immobilization in Organic Layers: Proteins can be collected from living organisms and repurposed in electronic devices. In my research, the enzyme glucose oxidase is taken from a fungus and immobilized in a biocompatible color-changing polymer matrix. The result is a biosensor for use by diabetics to measure his or her blood-sugar in real time. I am also working on a solar cell that would take advantage of the light-harvesting protein complex found in algae, combined with the proton transporting properties of trehalose sugar-glasses.
Information Entropy of the Genetic Code: Genetic mutations in even a single letter of DNA may cause hereditary diseases, including sickle-cell anemia. However, many mutations cause no problems at all. The chance that a single nucleotide polymorphism leads to a diseased state is strongly influenced by the chemical relatedness of the amino acid originally coded and the one actually produced. Many groupings of amino acids into related “families” have been proposed. My research uses the principles of information theory – which has many mathematical connections to the physics concept of thermodynamic entropy – to examine the inherent error-correcting features of the genetic code and evaluate which groupings best take advantage of its redundancy.
- NSU President’s Faculty Research and Development Grant (#335347)
- NSU Chapter – Society of Physics Students (SPS)
- US Patent #8,326,389: “A System for in vivo Biosensing Based on the Optical Response of Electronic Polymers.” A novel glucose monitoring system for the real-time measurement of blood sugar in patients with diabetes
- 2014 NSU Intramural Racquetball Doubles Champion